4th WCSET-2015 at Japan

 

Applied Sciences and Engineering:

Title:           Biodegradable nanomaterials to treat retinal diseases
Authors:      Bharath Raja Guru, Madiha Ahmad, Anusha Prabhu
Abstract:     One of the leading cause of aggravation of retinal diseases is neuroinflammation. Carticosteroids and Non-steroidal anti-inflammatory drugs (NSAIDs) are the mainstay therapy for treating these diseases. However, delivering effective doses of drug to the targeted tissue i.e. retina is the challenge. Since retina has blood- retina barrier, it is difficult to deliver drug through oral or intravenous route. The side effect of these drugs are also tremendous therefore it is almost impossible to deliver effective doses of drug for long time through traditional method. One promising approach is through intravitreal injections - Formulating drug encapsulated or conjugated nanoparticles using biodegradable and biocompatible polymers, injected into vitreous chamber of the eye. Nanoparticles will be preferentially taken up by retinal cells present in the posterior part of the eye and releases drug for very long time. The objective of this study is to formulate nanoparticles of Fluocinolone Acetonide (FA), a corticosteroid and Ibuprofen an NSAID, using Poly lactic co-glycolic acid (PLGA) and Poly ethylene Glycol (PEG) polymers as carriers for sustained release of the drugs administered through intravitreal injection to release effective doses of drug to retina. FA encapsulated optimized PLGA nanoparticles were obtained. Nano-conjugates of FA and PEG were successfully made and in vitro release of drug from the conjugate is also conducted. Cyclooxygenase-2[COX-2] suppression studies showed that the effect produced by all the ibuprofen nanoparticles formulations was much greater than that of free ibuprofen drug. This result substantiates that nanoparticles can be used to reduce neuro-inflammation to treat retinal diseases.

Keywords:   Biodegradable Polymer, Nanoparticles, Neuroinflammation, Retinal Drug Delivery, Intravitreal Route
Pages:         020-024

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