3th WCSET-2014 at Nepal

 

Applied Sciences Session:

Title:            Voltammetric and Spectroscopic studies on the interaction of Ketoconazole anti-fungal agent with Bovine Serum Albumin
Authors:       Mallappa M., Babu Giriya Gowda, C. C. Hadimani
Abstract:      The interaction between Ketaconazole (KTZ) an anti-fungal drug, and Bovine serum albumin (BSA) was investigated by voltammetric methods such as cyclic and Differential Pulse Voltammetry and different spectroscopic methods such as UV/visible spectrophotometry, spectroflourimetry and viscometric method were used to study the process. The voltammetric study of KTZ on GCE, the anodic peak was appeared at 0.667 V versus SCE corresponding peak current is -2.202×10-6A. The anodic peak currents were drastically decreased in the presence of BSA. The peak potential shift towards negative direction in CV and DPV suggested an electrostatic interaction, whereas Fluorescence spectra suggested that the quenching mechanism of the interaction of BSA to KTZ was a static quenching type. By the analysis of UV/Vis spectra, it was observed that KTZ had a high affinity with BSA which was indicated by the large binding constant.

Keywords:   Ketoconazole, Cyclic Voltammetry, Differential Pulse Voltammetry, Spectroscopy, Bovine Serum Albumin, Binding Constant
Pages:         618-625

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